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Postdoctoral Researcher - UC San Diego School of Medicine

Hiring Unit:

UC San Diego School of Medicine

Description:

A motivated and independent cancer biology postdoc scientist is sought to work on the identification of RNA and DNA modifications in hematological malignancies. The ideal candidate will have at a minimum, demonstrated molecular and cell biology expertise and experience with flow cytometry, Real-Time PCR, and in vivo mouse models. The successful candidate will design nucleic acid amplification primer and probes for detection of RNA and DNA modifications, clone/optimize lentiviral vectors, examine the developed assay in in vitro and in vivo leukemia models, and validate the function of these modifications using well-characterized clinical samples. The experience of flow cytometry, RT-qPCR, and handling BSL-2 (pathogen) is required.

Qualifications:

The successful applicant must work within an integrated multidisciplinary laboratory and be able to work with project scientists, technicians and students in the team. In addition, the candidate will be expected to report findings to PI and senior scientists.

Appointment Length/Period:

One year

Contact:

Dr. Qingfei Jiang
858-246-1477
q1jiang@ucsd.edu
Interested applicants should email a cover letter, CV, and contact information for three references to Dr. Qingfei Jiang.

For more information, click here.

Cancer Research Associate - UC San Diego School of Medicine

Hiring Unit:

UC San Diego School of Medicine

Description:

The Department of Medicine is responsible for fulfilling the teaching, research, and clinical missions of the University of California, San Diego and employs 486+ full-time salaried faculty members and 100+ academic appointees. Staff personnel include 600+ staff in 9 bargaining units, students, and volunteers. There are 250 clinical faculty practicing at multiple sites and hospitals.

Under supervision, the Research Associate will work in a translational hematology lab studying hematological malignancies. The incumbent will work with a variety of human blood and bone marrow samples and established human cell lines to study the onset, progression, and treatment of hematological malignancies. Incumbent will independently perform in vivo and in vitro assays such as flow cytometry, qPCR, lentiviral work, train new lab members, plan experiments, analyze data, and contribute to scientific papers. Incumbent will keep detailed records of all aspects of experimental data. Incumbent will assist in data preparation and drafting of manuscripts.

Minimum Qualifications:

  • Theoretical knowledge in molecular biology and biochemistry as typically attained by a Bachelor's degree, or an equivalent combination of education and experience.
  • Experience with all aspects of tissue culture including freezing, thawing, counting cells and splitting cultures.
  • Demonstrated skill in the operation and maintenance of various lab equipment such as confocal and quantitative fluorescent microscopes, centrifuges, nanodrop, IVIS imaging machine, and flow cytometer.
  • Experience in caring for and handling small lab animals (mice, rats, guinea pigs, and rabbits) and in administering medications and anesthesia to perform phlebotomy and minor surgical procedures on animals. Experience in Euthanizing small laboratory animals. Familiarity with the writing of Animal Subjects protocols and with the surgical procedures. Willingness and ability to work with rodents and/or other lab animals and/or infected samples.
  • Demonstrated experience working with human tissues; tissue trimming, histology analysis, and knowledge in necropsy.
  • Experience with standard repetitive techniques that may be required in research protocols related to a specific lab. Demonstrated ability to read, interpret and apply protocols in conducting research. Demonstrated ability in following step wise experimental protocols. Skill to troubleshoot adaptations of experimental protocols.
  • Demonstrated experience reading and using Material Safety Data Sheets. Demonstrated ability to follow established Safety and Biohazardous Material Guidelines.
  • Demonstrated experience working in and maintaining a sterile environment.
  • Experience in the design, construction, production, purification, and use of viral gene transfer vectors, including adenoviral, lentiviral and retroviral vectors.
  • Demonstrated skill in accurate record keeping and ability to organize, analyze, and calculate data. Knowledge in basic math for maintaining ledgers, income and expenditure reports.
  • Experience with the operation of a personal computer and software application, such as Access, MS Word and Excel. Knowledge to work with and learn new software for analysis.
  • Manual dexterity and legible handwriting. Ability to assist with general lab maintenance, including cleaning and restocking supplies and managing a regular schedule in the lab.
  • Strong communication skills (both verbal and written) needed to interact professionally and effectively in the work environment, as well as effectively and accurately document research procedures. Ability to read, comprehend and discuss research materials.
  • Enthusiasm for learning new techniques and a genuine interest in scientific research. Willingness and ability to learn new skills, research methods, and scientific principles. Ability to train students on same.
  • Good organizational and time management skills.
  • Knowledge of UCSD Environmental Health and Safety requirements including the ability to write with correct syntax and grammar and to clearly communicate ideas and protocols in writing to EH&S.
  • Knowledge sufficient to coordinate studies with other departments and the lab. Skill to plan and organize work assignments in an efficient and productive manner.
  • Demonstrated ability to assist in the writing of papers for publication, research proposals.
  • Experience with processing and ficolling patient peripheral blood and bone marrow in order to perform cryogenic database management. Scientific knowledge of DNA plasmids and primers.

Preferred Qualifications:

  • Theoretical knowledge of normal and malignant hematopoietic stem and progenitor cell biology sufficient to aid in the design and interpretation of experiments on those topics.

Special Conditions:

  • Employment is subject to a criminal background check.
  • Must be willing to work evenings and weekends when necessary.
  • Must be willing to work with small animals.
  • Must be willing to work with biohazardous and hazardous materials.
  • Must be willing to travel. Majority of time will be spent at Sanford Consortium for Regenerative Medicine 2880 Torrey Pines Scenic Drive La Jolla, CA 92037, but occasionally may need to travel to Moores Cancer Center 3855 Health Sciences Drive La Jolla, CA 92093.

To apply, click here.

Business Operations Analyst - Sanford Stem Cell Clinical Center

Hiring Unit:

Sanford Stem Cell Clinical Center 

Description:

Sanford Stem Cell Clinical Center at UC San Diego Health is accelerating innovative stem cell research into safe and effective patient diagnostics and therapy. We attract patients, funding agencies, and study sponsors to start novel stem cell clinical trials for the most challenging diseases.

Our team is a group of strategic thinkers who feel strongly about the role that stem cells have in modern research and the future of medicine. We’d like you to join us as we build the most compassionate, best scientific stem cell clinical research program.

The Business Operations Analyst plays a key role in business operations, fiscal management, staff administration, facilities management, and other special projects for Sanford Stem Cell Clinical Center – a $286M program to accelerate development of drugs and cell therapies that are inspired by and derived from current human stem cell research.

Key responsibilities include:

  • Support day-to-day business operations activities, including annual budget ($15M), grants management ($8M), staffing, and space & facilities management, and other program administration tasks.
  • Participate in the development of unique business strategies. Develops and performs special independent analytical projects that require analysis of complex information.
  • Analyze, track, control, and report on complex financial data from a variety of sources, including gifts, grants, contracts, and clinical trials.
  • Prepare budgets for grant applications, primarily to the California Institute for Regenerative Medicine.
  • Guide other staff and liaise with HHR on job descriptions, compensation programs, HR policies and procedures.
  • Facilitate space planning, construction, renovation, moves, and equipment inventory.

Minimum Qualifications:

  • A Bachelor's Degree in related area (business administration, economics, educational administration); and/or equivalent experience/training.
  • A minimum of two (2+) or more years of relevant experience.
  • Proven ability to develop, analyze, and carry out program and project objectives and work with others in achieving organizational goals.
  • Ability to research, gather, and organize information to produce clear and concise reports using various resources; ability to follow up with and monitor ongoing projects.
  • Competence in understanding interpreting, and effectively communicating procedures, policies, information, ideas and instructions. Working knowledge of human resources policies and procedures.
  • Demonstrated experience with grant proposal preparation and submission.
  • Proven experience in principles and practices of fund accounting, cost analysis, and audit procedures. Working knowledge of accounting principles, business math and bookkeeping for budget planning and analysis, and reconciling discrepancies. Experience analyzing financial data to develop budgets and monitor spending.
  • Strong analytical and problem-solving skills with ability to analyze situations, identify existing or potential problems, recommend solutions, determine and implement procedures to accomplish effective resolution.
  • Excellent writing skills and control of standard English, including grammar, spelling, and punctuation usage, to compose, edit and finalize business reports and correspondence. Solid communication and interpersonal skills to communicate effectively with staff verbally and written.
  • Working knowledge of common organization-specific and other computer application programs. Proven ability to utilize spreadsheets and databases to interpret, organize, and report on financial information.
  • Demonstrated experience with complex calendaring, travel, procurement, reimbursement, and event planning.
  • Solid organizational skills and ability to multi-task with demanding timeframes. Strong ability to prioritize occasionally heavy workload and meet multiple deadlines.

Preferred Qualifications:

  • Knowledge of UC human resources and personnel policies. Experience with staff recruitment within the UC system.
  • Familiarity with program announcements and grants made by California Institute for Regenerative Medicine (CIRM).
  • Knowledge of IFIS, Marketplace, FinancialLink, JDOnline, MyPayments, and MyTravel.
  • Experience assisting with space planning and analysis, facilities construction, renovation, and moves.

Special Conditions:

  • Employment is subject to a criminal background check.
  • Must be willing to work near labs where biological, chemical, and radiation hazards are present and animals and human embryonic stem cells are used in research.
  • Must be willing to enter labs for facilities and space responsibilities.

To apply, click here.