Approvals Needed for PIs Engaged in Work with iPSC 

"Projects involving the use of human pluripotent Stem Cells including hESC and hiPSC (both federally and non-federally funded) as defined above are subject to the review and approval of the ESCRO and IRB Committees prior to initiation of research or teaching."

Please start here

If you intend to use hiPSC lines (but not generate them yourself), you will need to complete the ESCRO face page, here: ESCRO Facesheet, and submit it as described below:

1. If you wish to use iPSC lines that have already been generated and that are available from another UCSD research PI, and if your experiments will be in vitro only, then

 a. You need administrative ESCRO Review obtained via UCSD IRB using the ESCRO Facesheet, submit on the UCSD IRB Website.

2. If you wish to use iPSC lines that have already been generated and that are available from a research PI at another institution, and if your experiments will be in vitro only, then

a. You need administrative ESCRO Review obtained via UCSD IRB using the ESCRO Facesheet, submit on the UCSD IRB Website.

b. You need an MTA to bring the iPS cells to UCSD.

3. If you wish to use iPSC lines that have already been generated and that are available from Corriell, ATCC or another commercial provider, and if your experiments will be in vitro only, then

a. You need administrative ESCRO Review obtained via UCSD IRB using the ESCRO Facesheet, submit on the UCSD IRB Website.

b. UCSD Procurement or the vendor will advise you of other needed forms when you place the order.

4. If you wish to generate iPSC from human somatic cells you collect from patients

 a. You need administrative ESCRO Review obtained via UCSD IRB using the ESCRO Facesheet, submit on the UCSD IRB Website.

b. You need Human Subjects review via UCSD IRB.

5. If you wish to generate iPSC from human somatic cells you purchase, or from cells already collected by another research lab or from a clinical collector

a. You need administrative ESCRO Review obtained via UCSD IRB using the ESCRO Facesheet, submit on the UCSD IRB Website.

b. You may be asked to show the consent or the protocol approval obtained by the other lab of collector

c. You need an MTA to bring the cells to UCSD.

6. If you wish to use human iPSC of any sort, obtained from any source, in an animal model

a. You need IACUC approval in addition to the  approvals above. 

UCSD Guidelines for Human Embryonic and Human Pluripotent Stem Cell Research

NAS/IOM Report on Stem Cell Ethics